Regulation in Information Systems Research (ISR) has garnered significant attention, especially since the global financial crisis of 2008 prompted a surge in regulatory measures. However, despite this growing importance, there remains a lack of comprehensive understanding regarding regulation in ISR. This research aims to evaluate the effectiveness of regulatory mechanisms amidst the backdrop of digital transformation. It explores the challenges posed by the rapidly evolving digital landscape and its impact on compliance and organizational functionality. The coexistence of regulation and ISR creates a complex interdependency ensuring adherence to standards, business conduct, and organizational dynamics. ISR plays a critical role in enabling organizations to maintain regulatory compliance while optimizing operational efficiency. Regulatory dictates significantly shape the adoption and adaptation of ISR strategies, necessitating seamless integration of compliance measures. Furthermore, governance elements undergo transformation amidst digital evolution, adding another layer of complexity. The research also investigates unexplored areas where refinement is needed to mitigate risks in the dynamic digital landscape. By elucidating the interplay between regulation, ISR, and evolving governance elements, the study provides a foundation for future research and contributes to enhancing regulatory frameworks to promote compliance and organizational agility. This evolution is crucial for ensuring the sustained success of enterprises in the evolving digital paradigm.