The cyber threat landscape is constantly evolving, with new tools and technological advancements changing how adversaries conduct cyberattacks. With the progression of Artificial Intelligence (AI) and AI tools being openly available for various uses, attackers can leverage AI to drive attacks. These types of attacks are termed "offensive AI." Offensive AI enhances adversaries and enables them to launch more targeted and complex attacks that can be conducted at a higher frequency and larger scale. This dissertation shall provide a holistic overview of (i) how offensive AI changes the threat landscape and (ii) the limitations of offensive AI.