This research explores the relationship between architecture and place attachment through an interdisciplinary neuroscience approach. Place attachment refers to the cognitive and emotional bond individuals develop with their surroundings, influencing their sense of belonging and well-being. The study examines how architectural design, informed by neuroscience, can enhance this bond. The built environment affects us both consciously and unconsciously, with up to 95% of our cognitive processes occurring outside our awareness. This research aims to bridge the gap between humancentered architectural design and our understanding of cognition, emotion,and memory. By combining architectural theory, neuroscience, and environmental psychology, the study investigates how design elements— such as materials, light, and spatial organization—affect place attachment. Data will be collected through surveys, interviews, architectural analysis, and neuroimaging (fMRI) to explore the neural mechanisms associated with place attachment. The goal is to develop design strategies that foster stronger emotional connections to spaces, promoting well-being and sustainable design practices.